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Full text: Mons, U., Muscat, J
These processes play key roles to promote chemoresistance in tumors, where elevated GSH inactivates electrophilic chemotherapeutic agents (cisplatin, alkylators), GSTs enable drug conjugation, and MRP-catalyzed efflux reduces intracellular drug levels - while inhibiting therapy-induced oxidative stress at the same time

doi: 10.1677/erc.1.01222

[DOI] [PubMed] [Google Scholar] 32.Posse S., Otazo R., Dager S.R., Alger J

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mineralocorticoid receptor (MR) activation in hepatocytes modulates cardiac repair post-MI via fibroblast growth factor 21 (FGF21), whereas an upstream IL-6STAT3 pathway suppresses MR expression, increasing cardioprotectiona dynamic liverto-heart feedback loop
