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Histoplasma capsulatum is endemic to tropical and subtropical regions of the Americas (Teixeira Mde et al., 2016

283 Mitochondria in aging and oxidative stress Harman proposed the free radical theory of aging in the 1950s, which hypothesized that the increase of free radicals, especially oxygen free radicals, would induce oxidative stress, causing damage to a variety of bioactive substances and accelerating aging

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However, the caveat is not in the lack of cobalamin in the diet

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