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2nd: dual autonomous mitochondrial cell death pathways are activated by Nix/BNip3L and induce cardiomyopathy

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Although we do not know the exact mechanism, we hypothesize that Ab68 antibody will have the same effect-suppressing inflammation by reducing the infiltration of inflammatory cells in multiple organs

This finding prompted the FDA to expand Wegovy's indication in March 2024 to include cardiovascular risk reduction

[DOI] [PubMed] [Google Scholar] 9.Galione A, Patel S, Churchill GC

Research background matters because peptide handling, sequence stability, and route-specific formulation all affect interpretation