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Pathological immobilisation of iron by protein aggregates such as amyloid and tau may sequester iron in a non-bioavailable form, or impaired autophagy may prevent efficient breakdown of ferritin to mobilise iron, thereby impairing mitochondrial ATP production and subsequently glutathione synthesis, an essential component of the ferroptosis defence system [29]

In particular, we observed that CD38 degrades NAD and decreases the accessibility of NAD to these enzymes [6, 34-35]

The relative abundance of the [ Eubacterium ] coprostanoligenes group was greater in both the vehicle- and 5A-1MQ-treated groups switched from WD to LD compared to the LD control group (Supplementary Fig

doi: 10.1111/j.1365-2265.2007.02774.x

& Luks, A

Peripheral tissue assays of ETC gene expression and complex activity are generally supportive of reduced mitochondrial function in bipolar depression