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The activated PARPase utilizes NAD + as a substrate to transfer ADP-ribose units one by one to the target protein, forming poly ADP-ribose chains

It plays a particularly strong role in the gut, acting throughout the digestive tract to aid digestion

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14-3-3 protein is a phosphoserine or phosphothreonine binding protein that is involved in various cellular processes, such as cell proliferation, apoptosis, and cell cycle (Morrison, 2009)