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Because the FOXO family of proteins show functional redundancy and share high sequence identity essentially for the FH and CR domains [54], we note that the binding mechanism previously identified for FOXO3 and TP53 [53] is valid for FOXO4 and TP53

Furthermore, a study found that cyclodextrin (-CD) greatly increases the solubility of drugs in combinations comprising acidic non-steroidal anti-inflammatory drugs and basic H2 blockers such as indomethacin-imidazole, histidine-imidazole where the solubility of the drug is enhanced by the interaction between the drugs

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It is a non-reactive and non-irritating ingredient

Abbreviations: D: dasatinib

TDP-43 aggregation induced by oxidative stress causes global mitochondrial imbalance in ALS