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Copyright: Nobel Foundation, Photo Hans Mehlin

[DOI] [PubMed] [Google Scholar] [48].Huang Q, Aluise CD, Joshi G, Sultana R, St Clair DK, Markesbery WR, Butterfield DA

This methodology presents an issue with linking mechanistic actions of endocrine disrupting chemicals to the risk of disease development since endocrine dysfunction, especially within estrogenic pathways (e.g., menopausal status, menstrual cycle length, early menarche, and contraception use), are typically associated with reasons for hysterectomy (Upson and Missmer, 2020)

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That is, low GSH could be due to low production of GSH OR it could be due to high production but also high reducing activity due to a high oxidative load (reflected in high levels of GSSG)

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