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Preclinical data suggest AHK-Cu may stimulate collagen and elastin production in dermal fibroblast models, with associated increases in dermal matrix density in animal studies, proposed to occur through AHK-Cu's modulation of VEGF and TGF-1 expression activating both fibroblasts (which build structural matrix proteins) and endothelial cells (which support the vascular network needed for tissue regeneration).[4] A separate in vitro study by Pyo et al

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Cheng, L., Liu, X., Lei, J

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