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no LD50 established even at very high doses in rodents No Hormonal Effects: Does not affect testosterone, estrogen, growth hormone, or other hormonal axes Gastric Origin: Derived from a naturally occurring human gastric protein, suggesting good biological compatibility Stability: Unusually stable in gastric acid, supporting oral administration potential Reported Effects: Anecdotal reports of fatigue, nausea in some research subjects TB-500 Safety Profile: (PMID: 20536472) Note: Published safety data is primarily available for Thymosin Beta-4

van den Maagdenberg et al., 2019)

Methods Enzymol 233:128140 Ubiyvovk VM, Blazhenko OV, Gigot D, Penninckx M, Sibirny AA (2006) Role of gamma-glutamyltranspeptidase in detoxification of xenobiotics in the yeasts Hansenula polymorpha and Saccharomyces cerevisiae

Prenatal exposure to progestins reduced estrogen receptor (ER) expression in the amygdala in the offspring, however, it can be reversed by postnatal or prenatal RSV treatment (41)

10.1016/j.jgg.2021.11.005 [DOI] [PubMed] [Google Scholar] Jiang Y., Zhao L., Chen Q., Zhou L

DRUG CATEGORIES The FDA identified 3 specific drug categories for human use to be included on the DDC lists