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In a clinical study of AD patients, alpha-lipoic acid slowed cognitive decline [234]

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This cascade of events may lead to initial autoimmune hypophysitis in genetically predisposed patients or to direct damage of the pituitary due to infection or by its inhibition by increased proinflammatory cytokines, resulting in decreased production of pituitary hormones, mainly ACTH

Other researchers suggest that cyanocobalamin does a better job maintaining B12 levels

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Neuroprotective and neuritogenic activities of novel multimodal iron-chelating drugs in motor-neuron-like NSC-34 cells and transgenic mouse model of amyotrophic lateral sclerosis