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Despite these major changes in myelin, OLs, and A immunoreactivity, no cognitive impairment or hippocampal pathology was detected in APP/PS1 mice after cuprizone treatment

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The strongest published finding is from the foundational Biochemical Pharmacology study by Neelakantan et al.: in diet-induced obese mice, daily 5-Amino-1MQ administration produced reductions in body weight, white adipose tissue mass, and adipocyte size without any significant change in food intake

There is limited information available on the effects of cuprizone intoxication on protein nitration in the rostral and caudal corpus callosum

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