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The amino acids L-citrulline and L-arginine both serve as food for NOS to produce NO from (see Figure), with L-citrulline being a precursor to L-arginine.[30],[31] In fact, a 2017 study found that lower serum levels of L-arginine and L-citrulline were more common in men having ED that was vasculogenic in nature.[32] Higher levels of arginine intake have been shown to be associated with higher serum levels of nitrite and nitrate.[33] Supplementation of L-arginine in combination with L-citrulline has been shown to have a greater impact on plasma L-arginine levels than either alone,[34] likely due in part to L-arginines extensive metabolism in the gut.[35] A 2019 systemic review and meta-analysis of randomized controlled trials concludes that supplementation with L-citrulline has a significant effect of lowering both diastolic and systolic blood pressure, with a greater effect in those with a baseline blood pressure of greater than 130/85 mmHg.[36] Studies of L-citrulline supplementation in athletes have shown a positive effect on performance with ongoing supplementation

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304,306 Gluten & Brain Function Celiac disease is an autoimmune condition in which antibodies to gluten (a protein found in wheat and several other grains) cause inflammation and tissue damage in the digestive mucosa

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