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For example, the DNA repair enzyme PARP1, and SIRTs 1 and 6, which are integral elements of the DNA repair response, are all critically dependent on NAD+ to function

It appears to interact with key biological systems, such as the nitric oxide pathway and antioxidant defenses, which may explain its broad therapeutic effects

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Long-term safety and efficacy of intramyocardial adenovirus-mediated VEGF-D(DeltaNDeltaC) gene therapy eight-year follow-up of phase I KAT301 study