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Therefore, both the increase in the survival of transformed B cells and the increase in antigen presentation generated by the increase in HLA-II expression by estradiol may favor an increase in the presentation of both self and foreign antigens during an infectious process, and those abnormal plasma cells producing autoantibodies survive longer, which consequently increases the probability of women developing autoimmune diseases or even cancer [171]

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This improved to a mean of 95 (range 85 to 100), classified as excellent function, at final follow-up ( P = 0.03125 Wilcoxon rank test, SPSS, version 22.0

Erol & Karpyak, Drug and Alcohol Dependence (2015)