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Referral to secondary care is indicated for severe or rapidly progressive neurological symptoms, diagnostic uncertainty, suspected bone marrow failure, or in pregnancy or paediatric cases

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Especially the B12 form of methylcobalamin has proven to be very effective in many studies

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Current Neuropharmacology, 14(8), 857-865

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Clinical trials would need to assess both hemodynamic parameters and clinical outcomes including walking distance, pain scores, and amputation rates to establish therapeutic benefit

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Thats changed, he says

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