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2020;8:e2843

It increases MMPs (e.g., MMP-2, MMP-9) activity and inhibits TIMPs (e.g., TIMP-1, TIMP-2) expression [149], promoting ECM degradation and reducing its accumulation

The net outcome hinges on the dynamic balance between prooxidant and antioxidant forces, ultimately influencing disease progression and therapeutic response

Rufat P

[DOI] [PMC free article] [PubMed] [Google Scholar] Hagen TM, Liu J, Lykkesfeldt J, Wehr CM, Ingersoll RT, Vinarsky V, Bartholomew JC, Ames BN

So, there is an obvious difference between the elimination rate and half-life of the two drugs, although both have similar drug clearance