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In addition, JHU-083 reduces the expression of IDO (an enzyme that mediates tryptophan metabolism) by inhibiting the phosphorylation of STAT1 and STAT3 in tumor cells, MDSCs, and TAMs, thereby decreasing the kynurenine/tryptophan ratio and enhancing the functions of antitumor T cells 150

10.1161/01.atv.20.9.2094 Arterioscler Thromb Vasc Biol

Mishra VH, Khade A, Noman O