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Vida media plasmtica : estimada en 30 minutos a 1 hora en rata tras administracin i.p., aunque los efectos biolgicos persisten 2472 h, sugiriendo accin tipo "trigger" sobre cascadas autosostenidas ms que ocupacin receptor continua

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High-dose B6 supplementation may be beneficial in the case of partial CBS activity to enhance residual enzyme function, while total enzyme deficiency requires a methionine-restricted diet, cysteine-supplemented diets and betaine, folate and B12 supplementation to promote alternate remethylation pathways (19,20)

Second generation transition state analogue inhibitors of human 5-methylthioadenosine phosphorylase

Dosage should be individualized for maximum beneficial effect