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These include: Endocrine (hormone) disorders, such as Cushing's disease and hypothyroidism (low thyroid hormones) Lipedema, a buildup of fat, most often in the legs, but sometimes in the arms as well Other rare fatty tissue disorders, such as Madelung's disease and familial multiple lipomatosis Your doctor might also order an imaging test, such as an MRI or ultrasound, to look at the fatty lumps inside your body and see if they look typical for Dercum's disease

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