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doi: 10.1136/jnnp.2009.194399 25 BoeynaemsS.BogaertE.KovacsD.KonijnenbergA.TimmermanE.VolkovA.et al

In addition, Kovcs et al

Song et al., 2023

For individuals who have problems with absorbing the vitamin, suffering from mild deficiency, pregnant women, a 1000 mcg dose is best

Lai et al., SCS macrophages suppress melanoma by restricting tumor-derived vesicle-B cell interactions

The published research on oral B12 bioavailability consistently shows around 1% absorption meaning of a 1000mcg oral dose, only about 10mcg actually reaches your cells