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Microglial phenotype modulation: Affects microglial gene expression shifting from pro-inflammatory M1 phenotype to anti-inflammatory M2 phenotype

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The clinical translation isnt established

J Pharmacol Exp Ther 283 164176 (1997)

While studies have shown that cAMP signaling has both inflammatory and anti-inflammatory effects, in myeloid cells, cAMP signaling is largely associated with a decrease in inflammation (Serezani et al., 2008

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