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Quantification was performed on three slides from each brain blinded to the study groups

There is a need for clinical guidelines, treatment algorithms and a greater number of validated biomarkers that could help clinicians match nutritional and lifestyle-medicine-based interventions to patients most likely to respond to different interventions

Long-chain fatty acids (LCFAs) cannot directly cross the mitochondrial membrane because of their high polarity and are activated to long-chain acyl-CoA by acyl-CoA synthetase (ACS)

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However, it is clear that C2 is involved with the regulation of metabolic flexibility since LC utilization and C2 production are important for maintaining glucose homeostasis [23]

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