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Front Mater 2:66

The level of reduced glutathione in intestinal tissue increased significantly and the ratio of CD4 + /CD8 + in different parts of intestinal mucosal immunity decreased significantly after 8 weeks of TGP administration in this study, suggesting that TGP may regulate lymphocytes in intestinal mucosal immunity and epithelial barrier through glutathione metabolism, thereby exerting an anti-RA effect
When loss is gain: reduced presenilin proteolytic function leads to increased A42/A40

Hyperglycaemia and Pseudomonas aeruginosa acidify cystic fibrosis airway surface liquid by elevating epithelial monocarboxylate transporter 2 dependent lactate-H+ secretion

doi: 10.1165/rcmb.2020-0085OC 97 WanRSrikaramPXieSChenQHuCWanMet al

If the TrxR1-, Gsr-, and Met-driven disulfide reductase systems play distinct roles in signaling and redox homeostasis, then it might be possible to target these pathways to selectively impact specific signaling activities versus homeostatic activities
