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p53 activation can suppress the mitochondrial tricarboxylic acid cycle and oxidative phosphorylation through inhibition of malic enzymes 1/2 or by inducing a PUMA-dependent metabolic switch (Jiang et al, 2013

[DOI] [PMC free article] [PubMed] [Google Scholar] 707.Wang Y, Wang L, Sun T, Shen S, Li Z, Ma X, et al

Frontiers in Aging Neuroscience 2: 12

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It is possible that glutathione depletion by 0.5 mM DEM triggers de novo glutathione biosynthesis as a compensatory mechanism to replenish glutathione