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Primary lymphedema occurs due to congenital defects in lymphatic network formation, which, alongside the cardiovascular system and blood cells, originates from the embryonic germ layer known as the mesoderm

It is usually induced in animal models by immunization with antigens from the thyroid, such as thyroglobulin or thyroid peroxidase, which induce the production of autoantibodies that attack thyroid cells (Liu et al

10.3390/molecules18089382 106 RasulA.KhanM.YuB.AliM.BoY

The approach to treatment is typically conservative at first, including non-surgical interventions like wrist splinting, avoidance of activities that might exacerbate the condition, and nonsteroidal anti-inflammatory drugs (NSAIDs) for pain relief

Luminescent and photofunctional transition metal complexes: from molecular design to diagnostic and therapeutic applications