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While efficacy matters, the tolerability and adverse effect profile often determines whether a treatment is suitable for long-term use

Lifestyle factors Sleep matters: Poor sleep elevates cortisol, increases hunger, and impairs fat loss

At first, I found the twisting and contorting in front of a full length mirror while fumbling with a syringe and needle was like playing the game Twister with a sharp object in a carnival funhouse

However, it is important to understand that 24 weeks, while substantial for clinical trials, provides limited information about safety with years-long continuous use

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