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accepted manuscript published online XXX

Some of these symptoms also can result from a variety of medical conditions other than vitamin B6 deficiency

The people with SPMS treated with natalizumab in the phase 3 ASCEND in SPMS trial (NCT01416181) had a decrease in their Multiple Sclerosis Impact Scale mean psychological scores from 39.1 at baseline to 36.7 at week 96, 21 which, although it was nonsignificant, was disconnected from longitudinal PROM changes with a steady decline in EDSS scores and the T25-FW

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