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doi: 10.1021/bi011802p

The antitumor activity of PHY906 stems from a multi-faceted mechanism, involving the inhibition of NF-B, matrix metalloproteases (MMPs), multi-drug resistant protein (MDR), and cytochrome P450 (CYP450), as well as the modulation of numerous cytokines

Systematic and high throughput screening in preclinical models, including DNA and RNA barcoding (Xue et al., 2024

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Venugopal S, MD, Issa GC, MD, Konopleva M, MD, PhD, DiNardo CD, MD, MSCE, Borthakur G, MD, Jabbour EJ, MD, Pemmaraju N, MD, Yilmaz M, MD, Short NJ, MD, Maiti A, MBBS, Sasaki K, MD, PhD, Masarova L, MD, Pierce SA, BSN, BA, Takahashi K, MD, PhD, Tang G, MD, PhD, Loghavi S, MD, Andreeff M , MD, PhD, Bhalla KN, MD, Garcia-Manero G, MD, Ravandi F, MBBS, Kantarjian H, MD, Daver N, MD

Genistein increased the number of primarily tiny colonies in the mouse lymphoma experiment, showing clastogenic properties