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The extracellular degradation of GSH occurs on the surface of the cells that express the enzyme -glutamyl transpeptidase and the dipeptidases found in the external plasma membrane (Figure 5)

[DOI] [PubMed] [Google Scholar] 19.Martinez-Martin P., Rodriguez-Blazquez C., Kurtis M.M., Chaudhuri K.R., Group N.V

Figure 4 GSTM3 Inhibited PC Cell Proliferation in vivo The xenograft tumor model was applied to explore the effect of GSTM3 on cell proliferation in vivo

Abbreviations HGF hepatocyte growth factor ICIs immune checkpoint inhibitors TME tumor microenvironment EMT epithelial-mesenchymal transition HNSCC head and neck squamous cell carcinoma RTKs receptor tyrosine kinases METex14 MET exon 14 skipping mutations NSCLC non-small cell lung cancer CAFs cancer-associated fibroblasts TAMs tumor-associated macrophages MDSCs myeloid-derived suppressor cells NK natural killer DCs dendritic cells ECM extracellular matrix Chi3L1 chitinase-3-like-1 Treg T regulatory CRC colorectal cancer GC gastric cancer IL-6R interleukin-6 receptor MMPs matrix metalloproteinases HIF1 hypoxia-inducible factor 1 IFN- interferon-gamma HCC hepatocellular carcinoma CTLs cytotoxic T lymphocytes MSCs Mesenchymal stromal cells CTLA-4 cytotoxic T-lymphocyte-associated protein 4 APCs antigen-presenting cells ORR objective response rate PFS progression-free survival OS overall survival GSK3 glycogen synthase kinase 3 Authors contributions YX, CYH, and MZ wrote the original draft and reviewed, edited, and prepared the figures and tables