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Identifying the specific gene-expression changes responsible for this persistence is an open research direction
We further administered LY294002 and L-NAME to rat models of GC-induced ONFH to elucidate the angiogenic effects of GDF11 in vivo, PI3K-antagonist group was treated with 0.5 mg/kg LY294002 via intraperitoneal (i.p.) injection, eNOS-antagonist group was treated with 20 mg/kg L-NAME, groups were administered daily for 3 consecutive weeks from the second day after MP injection
Most of these substances do not have an immediate effect after a single administration and must be used for some length of time before there is a measurable improvement
It comes as a white freeze-dried powder sitting in a clear glass vial
10.3390/bioengineering6010022 Bioengineering 9 Di MiccoR.KrizhanovskyV.BakerD.DaddaDi FagagnaF
