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ii) Upregulation of Nrf2 gene expression at the transcriptional level in response to ARE inducers.177iii) activation of PKC by oxidative stress and electrophiles which, in turn, activates Nrf2 through the phosphorylation of a serine residue located in the N-terminal region.178,179 5

Our findings support several preliminary studies showing that blocking TRPV1 suppressed myofibroblast formation and expression of TGF1 in cultured keratocytes or ocular fibroblasts [31, 32]

[DOI] [PMC free article] [PubMed] [Google Scholar] Crapper McLachlan DR, Dalton AJ, Kruck TPA, Bell MY, Smith WL, Kalow W, Andrews DF

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doi: 10.20960/nh.2431, 55