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The Association between Mushroom Consumption and Mild Cognitive Impairment: A Community-Based Cross-Sectional Study in Singapore

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Glutamine could delay fatigue by several mechanisms: (i) it is one of the most abundant glycogenic amino acids in humans and animals, having a significant influence on the anaplerosis of the Krebs cycle and gluconeogenesis [14,15], (ii) through the activation of glycogen synthase, glutamine is considered as a direct stimulator of glycogen synthesis [7,16], (iii) this amino acid is the main non-toxic ammonia carrier, avoiding the accumulation of this metabolite [14], (iv) glutamine is also linked to attenuation of muscle damage and is considered an indirect antioxidant via stimulation of glutathione synthesis [17,18], among others

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As free radicals are produced during normal physiological processes, antioxidant defense mechanisms must be in place to prevent the accumulation of these reactive species