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Methods Datasets used L

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Unlocked nucleic acid-an RNA modification with broad potential

While we used several markers (including SA--gal, lipofuscin, cyclin-dependent kinase inhibitors, SASP components and transcriptional senescence signatures) to characterize senescence in these models, we have to acknowledge the limitations of our study given the inherent heterogeneity of senescent cells

Although the exact lead variants were not always present in the external datasets, nearby variants within these loci showed statistically significant associations and concordant direction of effect, supporting locus-level consistency across populations

[DOI] [Google Scholar] 62.Rayatdoost E., Chegin M., Taghipour A., Shadmand E., Rezaei F., Falahi S., Kenarkoohi A., Badri M., Solhjoo K., Abdoli A