glutathione for catalyzing disulfide formation Mechanistic insights on the reduction of by protein disulfide isomerase Oxidant-induced glutathionylation at protein disulfide

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The outstanding compound, 67 , had an IC 50 value of 0.018 M and was comparable to topiroxostat, which had an IC 50 of 0.013 M (Figure 21)

doi: 10.3389/fphar.2021.627533 Goldstein, A

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In fibrosis, clinical trials show promise for focal segmental glomerulosclerosis and diabetic kidney disease using anti-ligand antibodies, for scleroderma/skin fibrosis using a topical betaglycan mimetic peptide, and for idiopathic pulmonary fibrosis, glomerulosclerosis and diabetic kidney disease with pirfenidone