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The gene involved is the MTHFR (Methylenetetrahydrofolate Reductase) gene

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Thus, Leishmania inhibits Janus kinase 2-signal transducer and activator of transcription 2 (JAK2-STAT1) and extracellular-regulated kinase 1-activator protein 1 (ERK1/2-AP1) signaling cascades, thereby preventing iNOS expression ( L

[DOI] [PubMed] [Google Scholar] 177.Kullisaar T., Turk S., Punab M., Mandar R

Upon stimulation, these subunits come together to form the activated enzyme complex [55,56]