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Synthetic lethality of combined ULK1 defection and p53 restoration induce pyroptosis by directly upregulating GSDME transcription and cleavage activation through ROS/NLRP3 signaling

P., Bounous, G., Baruchel, S., Lee, T

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A human putative lymphocyte G0/G1 switch gene containing a CpG-Rich island encodes a small basic protein with the potential to be phosphorylated

Hence, it is possible that exploiting ferroptosis-related therapeutic regimens may be a novel measure for treating tumors (Figure 3)