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An additional indicative point is sequential involvement

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In addition to the induction of type I IFNs via phosphorylated IRF3, the activated cGAS-STING signaling cascade also induces the NF-B signaling pathway, leading to the production of inflammatory cytokines like IL-6 or TNF-, chemokines such as CXCL10 and cell cycle regulators (104, 270272)

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