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Description
Physiol Genomics 34 , 112126, doi: 10.1152/physiolgenomics.00239.2007 (2008)

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High-dose free curcumin exhibits dose-dependent hepatotoxicity, mechanistically arising from mitochondrial dysfunction, ROS overproduction, and activation of necroptosis pathways involving RIPK1/RIPK3 complexes in hepatic cells [74]

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