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However, prolonged exposure of neurons to glutamate leads to cell death by elevating the intracellular Ca 2+ that subsequently generates free radicals and induces apoptosis in the neuronal cells (Ola et al., 2013)

In fact, the increased expression of glycolytic enzymes, such as HK2, which catalyze the first step in glucose metabolism, PFKFB, which plays a critical role in regulating glycolysis in the cytoplasm, and PDK1, a key enzyme that acts between glycolysis and tricarboxylic acid (TCA) cycle, supporting the idea that increased glycolysis could induce a more aggressive FLS phenotype 17,21,22,23

A., Puskarjov, M

[DOI] [PubMed] [Google Scholar] 58.Hirshburg J.M., Kelsey P.A., Therrien C.A., Gavino A.C., Reichenberg J.S

The Opportunistic Human Pathogenic Fungus Aspergillus fumigatus Evades the Host Complement System

Clearly methylation is a critical processas well as a complicated one
