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The prevalence of at least moderate OSA (AHI 15) varies greatly among the elderly, with studies using different methodologies reporting prevalence as low as 7% to as high as 44%

In addition, it can also be associated with other medical conditions including epilepsy, congenital cardiac defects, gastrointestinal (GI), immunological, endocrine/metabolic and sleep disorders, as well as psychiatric comorbidities like ADHD and anxiety

Accordingly, therapy with methotrexate, which is used for different autoimmune conditions including IBD, appears to suppress glycolytic mechanisms in varied immune cell populations (205), counteracting the metabolic reprogramming associated with disease pathophysiology