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It is used under medical supervision when a patients natural GH levels are abnormally low

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31 Phenformin has been reported to exhibit anti-thiamine activity in animals, 3234 and as a result, it has been suggested that a possible anti-thiamine effect of metformin might contribute to some cases of metformin-associated lactic acidosis, a rare condition, but one that has been shown to have a mortality rate of 1825%
where available, cite modelspecific data to support claims

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Important caveat: there are no completed human efficacy trials of the TB-500 fragment itself