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These data support a continuum of beta cell dysfunction that is molecularly distinct from mere cell loss and highlights the importance of preserving differentiated beta cell state

The mean change from baseline in the ARA 290 group was 8.3 13.3 m and for placebo was 12.9 13.9, neither of which constituted a significant change from baseline ( p = ns

Prez-SnchezABarrajn-CatalnECaturlaNCastilloJBenavente-GarcaOAlcarazMet al

Introduction Asthma, a chronic inflammatory disease of the lung, affects up to 300 million people worldwide and remains a major cause of morbidity and mortality (1, 2)

Although opioids predominantly undergo hepatic metabolism, specific metabolic pathways vary by agent and pharmacokinetic data in patients with severe hepatic impairment are limited