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demonstrated that Gln deprivation reduces the levels of key TCA cycle intermediates, thereby inhibiting tumor cell proliferation [51]

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It is mediated by inflammasome-activated Gasdermin proteins that form membrane pores to cause cell lysis and passive release of pro-inflammatory cytokines (e.g., IL-1), which amplifies immune responses against pathogens or tumor cells [14,15,16,17,18,19]

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Low levels of B12 can also be associated with those who have anemia or certain autoimmune disorders, and some prescription medications can also interfere with vitamin absorption