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This modulation of the immune response not only alleviates symptoms but also promotes long-term healing of the intestinal tissues

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GSCPs-MNs promoted cell proliferation and collagen synthesis, downregulated the secretion of the inflammatory factors TNF- and IL-1, and ultimately improved vascularization around HFs

pylori infection inhibits calcium and other nutrient absorption, reduces estrogen levels, increases inflammatory signaling, and alters levels of other signaling molecules from the stomach leading to increased bone loss and risk of osteoporosis
Hypoxia tends to maintain the levels of Hypoxia Inducible Factor (HIF-1), which regulates numerous cellular processes, including angiogenesis and proliferation, and as a result, can cause delayed wound healing ( Extracellular matrix The Extracellular matrix is a key environmental component in healing diabetic wounds, as it acts as a dynamic scaffold for cells and facilitates tissue development and regeneration ( Figure 2 )

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