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Proteotoxic stress A cellular condition caused by the accumulation of misfolded, aggregated or damaged proteins, overwhelming the protein quality control systems and disrupting normal cellular function

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J Cardiovasc Med (Hagerstown)

The study's lead compound, 75 , showed satisfactory inhibition against XO with an IC 50 value of 0.20 nM, which was higher than febuxostat and topiroxostat (Figure 24)

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