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An unexpected link between fatty acid synthase and cholesterol synthesis in proinflammatory macrophage activation

Instead of promoting GSH-conjugation reactions, cysteine-containing GSTs (Cys-GSTs) are able to perform deglutathionylation reactions similarly to glutaredoxins but the targets are usually different since glutaredoxin substrates are mostly oxidized proteins and Cys-GST substrates are metabolites

Acyl-coenzyme A synthetase long-chain family (ACSL) 4 and lysophosphatidylcholine acyltransferase 3 are critical for ferroptosis because they promote the activation and incorporation of PUFAs into membrane lipids

If youre feeling worse in a week, then talk to your doctor about maybe switching things up

PMID: 171 DuanXCPengLYYaoXXuMQLiHZhangSQet al

ALSUntangled 44: curcumin