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doi: 10.1002/jbm.b.31150

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In a recent study, after administering a loading dose, the authors utilized the maintenance dose algorithm to target a colistin steady-state concentration of 2.5 mg/L

Indeed, evidence suggests that peripheral innate immune system molecules can trigger a secondary neuroinflammatory response in the central nervous system (CNS) 8,9,10

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Reduced-frequency alternatives include 2 to 3 mg three times per week or 2 mg every other day, producing similar weekly exposure with fewer injections