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doi: 10.1083/jcb.149.1.13

Studies have been published which report that the use of nonsteroidal anti-inflammatory drugs cause a depletion of glutathione levels.[1] ,[2],[3] Commonly used NSAIDs include: ibuprofen (Advil, Motrin, Nuprin), naproxen (Aleve), piroxicam (Feldene) and ketoprofen (Orudis) as well as many prescription strength NSAID

Irani M, Amirian M, Sadeghi R, Lez JL, Latifnejad Roudsari R

First, antioxidant therapy could not decrease oxidative stress in patients with neurodegenerative diseases potentially due to insufficient dose of antioxidants, unsuitable timing for therapy, or inappropriate duration of treatments [138]

It helps support antioxidant recycling, detoxification pathways, immune function, mitochondrial health, and cellular repair

Another strategy is to use 4-hydroxythalidomide as the starting building block to create ether-linked 4-hydroxythalidomide derivatives 96