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Ubiquitin-dependent lysosomal degradation of GPCRs and long-term desensitization GPCR ubiquitination, as shown initially for the 2 AR and the chemokine receptor CXCR4, is a critical tag that directs internalized receptors to lysosomes, although initial agonist-induced endocytosis of these receptors does not require receptor ubiquitination [70, 77]

Conclusion and perspectives AKI is a serious public health problem with high morbidity and mortality, and an in-depth understanding of the characteristics and pathogenesis of disease is an effective strategy to prevent and treat this disease