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HPLC-grade acetonitrile, formic acid, and methanol were obtained from Merck (Darmstadt, Germany)

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This inherent restriction has significantly limited the availability of effective AD treatments and has triggered investigation into methods or strategies to bypass the BBB

For example, the 2-oxoglutarate carrier capacity changes with mitochondrial membrane fluidity: in rat liver mitochondria enriched in cholesterol, a decrease in mitochondrial GSH uptake was found [67]

10.1038/mp.2012.77 Mol Psychiatry

In this trial, patients received NA starting with 250 mg750 or 1000 mg per day over a course of four months, with the last follow-up 10 months later
